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TC-H 106

Cat. No. M7374

All AbMole products are for research use only, cannot be used for human consumption.

TC-H 106 Structure
Synonym:

Pimelic Diphenylamide 106; RGFA-8; Histone Deacetylase Inhibitor VII

Size Price Availability Quantity
5mg USD 50 In stock
10mg USD 85 In stock
25mg USD 135 In stock
50mg USD 220 In stock
100mg USD 330 In stock
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Quality Control & Documentation
Biological Activity

TC-H 106 is a class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). TC-H 106 exhibits slow, tight-binding inhibitory activity. TC-H 106 displays no activity against class II HDACs. Brain penetrant.

Chemical Information
Molecular Weight 339.43
Formula C20H25N3O2
CAS Number 937039-45-7
Solubility (25°C) DMSO 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Maria Beconi, et al. PLoS One. Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo

[2] Anindita Chakrabarty, et al. Proc Natl Acad Sci U S A. Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

[3] Chunping Xu, et al. Chem Biol. Chemical probes identify a role for histone deacetylase 3 in Friedreichs ataxia gene silencing

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Keywords: TC-H 106, Pimelic Diphenylamide 106; RGFA-8; Histone Deacetylase Inhibitor VII supplier, HDAC, inhibitors, activators

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