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TBOPP

Cat. No. M20753

All AbMole products are for research use only, cannot be used for human consumption.

TBOPP Structure

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Biological Activity

TBOPP is a selective inhibitor of dedicator of cytokinesis (DOCK1, Dock180) that inhibits DOCK1-mediated Rac activation with IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with Kd of 7.1 μM. TBOPP exhibits anti-tumor activity.

Chemical Information
Molecular Weight 490.49
Formula C24H21F3N2O4S
CAS Number 1996629-79-8
Solubility (25°C) DMSO 98 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jin H Song, et al. Biochim Biophys Acta Mol Basis Dis. TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation

[2] Junru Feng, et al. Protein Cell. Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer

[3] Wei Zhang, et al. Mol Med Rep. TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma

[4] Hirotada Tajiri, et al. Cell Rep. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

[5] Glen A Franklin, et al. J Trauma. Decreased juvenile arson and firesetting recidivism after implementation of a multidisciplinary prevention program

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Keywords: TBOPP supplier, inhibitors, activators

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