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TBAJ-587 

Cat. No. M29445

All AbMole products are for research use only, cannot be used for human consumption.

TBAJ-587  Structure
Size Price Availability Quantity
5mg USD 240 In stock
10mg USD 360 In stock
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Quality Control & Documentation
Biological Activity

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization.

Chemical Information
Molecular Weight 614.5
Formula C30H33BrFN3O5
CAS Number 2252316-16-6
Form Solid
Solubility (25°C) DMSO 43.33 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Tanveer Ahmad, et al. J Org Chem. Synergistic Li/Li Bimetallic System for the Asymmetric Synthesis of Antituberculosis Drug TBAJ-587

[2] Si-Yang Li, et al. Antimicrob Agents Chemother. Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model

[3] Todd A Black, et al. J Clin Tuberc Other Mycobact Dis. The pipeline of new molecules and regimens against drug-resistant tuberculosis

[4] Jian Xu, et al. Antimicrob Agents Chemother. Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis

[5] Neelagandan Kamariah, et al. Prog Biophys Mol Biol. Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design

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Keywords: TBAJ-587  supplier, Antibiotic, inhibitors, activators

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