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Tazarotenic acid

Cat. No. M8586

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Tazarotenic acid Structure

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Quality Control & Documentation
Biological Activity

Tazarotenic acid, an active metabolite of tazarotene, is a potent and selective agonist of the retinoid receptor (RAR) that binds to RARα, RARβ, and RARγ. Tazarotenic acid relatively selective activates RARβ and RARγ. Tazarotenic acid is a first xenobiotic substrate of human retinoic acid hydroxylase CYP26A1 and CYP26B1.

Chemical Information
Molecular Weight 323.41
Formula C19H17NO2S
CAS Number 118292-41-4
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yu-Ting Lu, et al. Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies

[2] Robert S Foti, et al. Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1

[3] Ying Tong, et al. Simultaneous determination of tazarotene and its active metabolite tazarotenic acid in minipig plasma by LC-MS/MS and its application in pharmacokinetic study after topical administration of tazarotene gel

[4] Mayssa Attar, et al. Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans

[5] William Abramovits, et al. Treatment of warty dyskeratoma with tazarotenic acid

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Keywords: Tazarotenic acid supplier, inhibitors, activators

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