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Tazarotene is a member of the acetylenic class of retinoids which binds at retinoid acid receptors (RAR) -β and -γ. Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis. Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. It is also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect.
| Molecular Weight | 351.46 |
| Formula | C21H21NO2S |
| CAS Number | 118292-40-3 |
| Solubility (25°C) | DMSO >30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Duvic M, et al. J Am Acad Dermatol. Molecular mechanisms of tazarotene action in psoriasis.
| Related RAR/RXR Products |
|---|
| Acitretin (Ro 10-1670)
Acitretin (Ro 10-1670) is a second-generation retinoid. |
| Adapalene
Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene is also an MST1 agonist. |
| Tamibarotene
Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. |
| TTNPB
TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. |
| Fenretinide
Fenretinide (4-HPR) is a synthetic retinoid deriverative. Fenretinide is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death. |
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