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TAT-DEF-Elk-1 acetate (TDE acetate) is a cell-penetrating peptide inhibitor of Elk-1 that achieves inhibition by mimicking and specifically interfering with the DEF structural domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation.
Sequence: Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Ser-Pro-Ala-Lys-Leu-Ser-Phe-Gln-Phe-Pro-Ser-Ser-Gly-Ser-Ala-Gln-Val-His-Ile.
| CAS Number | 1220751-16-5 (free base) |
| Solubility (25°C) | Water 5 mg/mL |
| Storage | Store at ≤ -20°C, dry, sealed |
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