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TASP 0390325 is a potent and orally active, selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptors). In the range of 10 μM, there was no significant affinity for the other 85 receptors, ion channels and transporters, including V1A and V2. ACTH level was increased by TASP 0390325 in rats. TASP 0390325 is an antidepressant and anti-anxiety compound.
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| Animal models | Male Sprague-Dawley (SD) rats |
| Formulation | suspended in 0.5% methylcellulose 400 |
| Dosages | 0.3 and 1 mg/kg |
| Administration | Oral administration |
| Molecular Weight | 554.44 |
| Formula | C25H29ClFN5O4.HCl |
| CAS Number | 1642187-96-9 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| Tolvaptan
Tolvaptan is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28μM for the inhibition of AVP-induced platelet aggregation. |
| Conivaptan hydrochloride
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| Atosiban Acetate
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| L-371,257
L-371,257 is a potent and selective oxytocin receptor antagonist. |
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