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TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (IC50 of 4.8, 1.6 and 44 nM for Akt1, 2 and 3, respectively).TAS-117 stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition.TAS-117 induces apoptosis and autophagy. autophagy).
| Molecular Weight | 424.49 |
| Formula | C26H24N4O2 |
| CAS Number | 1402602-94-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Naoya Mimura. Rinsho Ketsueki. [Novel epigenetic therapies for multiple myeloma]
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