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Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor. Tarloxotinib has the potential to effectively shut down aberrant EGFR signaling in a tumor-selective manner, thus potentially avoiding or reducing the systemic side effects associated with currently available EGFR tyrosine kinase inhibitors.
| Molecular Weight | 681.77 |
| Formula | C24H24Br2ClN9O3 |
| CAS Number | 1636180-98-7 |
| Solubility (25°C) | DMSO ≥ 28 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Ahmed Salem, et al. Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome
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