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The hydroxamate-based AspR1 probe, which shares structural features with GM6001 and TAPI-0 covalently labeled the recombinant chlamydial PDF, and furthermore, GM6001 and TAPI-0 competed off the probe in the labeling of the parasitic enzyme.
| Cell Experiment | |
|---|---|
| Cell lines | pLysS cells |
| Preparation method | Extracts prepared from untransformed pLysS cells or from the bacteria transformed with the pET21-PDF vector were mixed with 1 μM probe in the presence or absence of excessive GM6001 or TAPI-0 or GMNC. |
| Concentrations | 1 μM |
| Incubation time | 1 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 456.54 |
| Formula | C24H32N4O5 |
| CAS Number | 143457-40-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
|---|
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| Batimastat
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| NSC 405020
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| Marimastat
Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. |
| Apigenin 7-O-glucuronide
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