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Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.
| Molecular Weight | 573.56 |
| Formula | C27H27N9O6 |
| CAS Number | 113857-87-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[3] Effrosyni Apostolidou, et al. Drugs. Treatment of acute lymphoblastic leukaemia : a new era
| Related Antifolate Products |
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| Methotrexate
Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| Folinic acid calcium salt
Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| Sulfamethazine
Sulfamethazine is a sulfonamide antibacterial. |
| Pyrimethamine
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
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