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Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities.
| Molecular Weight | 214.07 |
| Formula | C9H19BN2O3 |
| CAS Number | 149682-77-9 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Haitao Guo, et al. Curr Protoc Immunol. Inflammasome Assays In Vitro and in Mouse Models
[3] Gabriele Fenini, et al. Int J Mol Sci. The NLRP1 Inflammasome in Human Skin and Beyond
[5] Charles Casey Cunningham. Expert Opin Investig Drugs. Talabostat
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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