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TAK-700 (Orteronel) selectively inhibits the enzyme CYP17A1 which is expressed in testicular, adrenal, and prostatic tumor tissues. 17,20-Lyase inhibition by orteronel was tolerable and results in declines in PSA and testosterone, with evidence of radiographic responses.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Adult male cynomolgus monkeys. |
| Formulation | TAK-700 is dissolved in 0.5% methylcellulose. |
| Dosages | ≤1 mg/kg |
| Administration | Administered via p.o. |
| Molecular Weight | 307.35 |
| Formula | C18H17N3O2 |
| CAS Number | 566939-85-3 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL Ethanol ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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