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Tadalafil (Cialis) is a PDE inhibitor. Tadalafil (Cialis), which has demonstrated a high level of selectivity for PDE5 over the other phosphodiesterases, has shown efficacy in improving erectile function and sexual satisfaction in phase III trials. PDE11A3, PDE11A2, and PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibition by Tadalafil (Cialis).
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Sham-operated rats |
| Formulation | Saline |
| Dosages | 2 mg/kg |
| Administration | Orally |
| Molecular Weight | 389.4 |
| Formula | C22H19N3O4 |
| CAS Number | 171596-29-5 |
| Solubility (25°C) | DMSO 48 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Fabiola Zakia Mnica, et al. Tadalafil for the treatment of benign prostatic hyperplasia
| Related PDE Products |
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GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM. *The compound is unstable in solutions, freshly prepared is recommended |
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BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). |
| Roflumilast
Roflumilast (APTA-2217; BYK 20869; B9302-107) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4). |
| Piclamilast
Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4. |
| Apremilast
Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
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