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Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and reduces depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Tacrine hydrochloride has been shown to inhibit acetylcholinesterase (AChE) with IC50 of 31 nM.
| Molecular Weight | 234.72 |
| Formula | C13H14N2.HCl |
| CAS Number | 1684-40-8 |
| Solubility (25°C) | DMSO 40 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Maja Przybyłowska, et al. Therapeutic Potential of Multifunctional Tacrine Analogues
[2] Martin Horak, et al. The pharmacology of tacrine at N-methyl-d-aspartate receptors
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