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TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells.
TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively. TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers. TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression.
| Molecular Weight | 641.56 |
| Formula | C28H25BrN4O5S2 |
| CAS Number | 1429321-13-0 |
| Solubility (25°C) | DMSO 40 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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