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T-3764518 

Cat. No. M56794

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T-3764518  Structure

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Quality Control & Documentation
Biological Activity

T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.

Chemical Information
Molecular Weight 473.37
Formula C20H17F6N5O2
CAS Number 1809151-56-1
Form Solid
Solubility (25°C) DMSO 95 mg/mL
Storage 4°C, protect from light, dry, sealed
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MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.

Aramchol

Aramchol is a novel fatty acid bile acid coupling agent with oral activity and an inhibitor of SCD1, which acts by inhibiting SCD1 expression in hepatocytes and hepatic astrocytes, and can be used in studies related to non-alcoholic steatohepatitis (NASH).

CVT-12012

CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

CAY10566

CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. CAY10566 blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM)

GSK1940029

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  Catalog
Abmole Inhibitor Catalog




Keywords: T-3764518  supplier, Stearoyl-CoA Desaturase, inhibitors, activators

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