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SYM2206 is a novel, potent and non-competitive AMPA receptor antagonist with IC50 value of 2.8 μM. SYM-2206 exerts anticonvulsant effects, elevates the threshold for maximal electroshock-induced seizures in mice. Glutamate receptor antagonists SYM2206 (0-100 µM) on cell viability of PANC1 and PaTu-8988t cells after 72 hours of incubation as assessed by MTT assays. SYM2206 dose-dependently inhibited the viability of both cell lines, suggesting that therapeutic interference with glutamate receptor signaling by application of AMPAR antagonists might represent a new treatment approach for pancreatic cancer.
| Molecular Weight | 366.41 |
| Formula | C20H22N4O3 |
| CAS Number | 173952-44-8 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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