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SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH.
| Molecular Weight | 376.23 |
| Formula | C19H15Cl2NO3 |
| CAS Number | 2376322-12-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Epoxide Hydrolase Products |
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| Pentyl Chloroformate
Certain substituted caprolactam carbonates and ethers, compound compositions containing them and their use in the study of tumors. |
| TPPU
TPPU is a potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant. |
| AUDA
AUDA is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. |
| Valpromide
Valpromide (VPD) is a derivative of valproic acid (VPA) and is used as an antiepileptic drug. |
| EC5026
EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. |
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