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Suvratoxumab

Cat. No. M24753

All AbMole products are for research use only, cannot be used for human consumption.

Suvratoxumab Structure
Synonym:

MEDI4893

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Quality Control & Documentation
Biological Activity

Suvratoxumab (MEDI4893) is a long-acting, high-affinity humanized anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin or Linezolid .

Chemical Information
CAS Number 1629620-18-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Bruno François, et al. Lancet Infect Dis. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial

[2] C Tkaczyk, et al. Antimicrob Agents Chemother. Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models

[3] Bas G J Surewaard, et al. Cell Host Microbe. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

[4] Vaheh Oganesyan, et al. J Biol Chem. Mechanisms of neutralization of a human anti-α-toxin antibody

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Keywords: Suvratoxumab, MEDI4893 supplier, Anti-infection, inhibitors, activators

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