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Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator, with EC50 of 0.8 μM. Supercinnamaldehyde covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.
| Molecular Weight | 201.22 |
| Formula | C12H11NO2 |
| CAS Number | 70351-51-8 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 2-8°C, sealed |
[1] Spartak Yanakiev. Effects of Cinnamon ( Cinnamomum spp.) in Dentistry: A Review
[2] Amanda A Doyle, et al. A review of cinnamaldehyde and its derivatives as antibacterial agents
[4] Su-Hyung Hong, et al. Cinnamaldehydes in Cancer Chemotherapy
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