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Sunvozertinib (DZD9008) is an effective inhibitor of ErbBs (EGFR, Her2, especially EGFR Exon20ins mutants) and BTK. Sunvozertinib showed EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and IC50 of Her2 exon 20 YVMA and EGFR WT A431 They are 20.4, 20.4, 1.1, 7.5 and 80.4 nM respectively (please refer to patent WO2019149164A1, Example 52 for details).
| Molecular Weight | 584.08 |
| Formula | C29H35ClFN7O3 |
| CAS Number | 2370013-12-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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