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Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells and reduces tumor burden in adenomatous polyposis patients.
| Molecular Weight | 340.41 |
| Formula | C20H17FO2S |
| CAS Number | 32004-67-4 |
| Solubility (25°C) | DMSO: ≥22 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Mohanad Zbidah, et al. Sulindac sulfide--induced stimulation of eryptosis
[5] C Herrmann, et al. Sulindac sulfide inhibits Ras signaling
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