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Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.
| Cell Experiment | |
|---|---|
| Cell lines | neuroblastoma cells |
| Preparation method | Cell viability of hippocampal slices subjected to OGD with or without sulbutiamine was determined by TO-PRO-3 iodide staining (dilution 1 : 1000). |
| Concentrations | 1, 10 and 50 μM |
| Incubation time | 15 min |
| Animal Experiment | |
|---|---|
| Animal models | Rats |
| Formulation | Arabic gum, 15% w/v |
| Dosages | 12.5 mg/kg |
| Administration | i.p. |
| Molecular Weight | 702.89 |
| Formula | C32H46N8O6S2 |
| CAS Number | 3286-46-2 |
| Solubility (25°C) | 75 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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