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Streptolydigin

Cat. No. M30537

All AbMole products are for research use only, cannot be used for human consumption.

Streptolydigin Structure
Synonym:

Portamycin

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Quality Control & Documentation
Biological Activity

Streptolydigin (Portamycin) is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor with a Ki of 18 μM and a Kd of 15 μM. Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin possess potent antibacterial activity, particularly against anaerobes and some Gram-positive aerobes.

Chemical Information
Molecular Weight 600.7
Formula C32H44N2O9
CAS Number 7229-50-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Alexander Speer, et al. Tuberculosis (Edinb). Mycobacterium tuberculosis is resistant to streptolydigin

[2] Cristina Gómez, et al. Microbiology (Reading). Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus

[3] Guang-Rong Zhao, et al. Appl Microbiol Biotechnol. fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin

[4] K Severinov, et al. J Biol Chem. Streptolydigin-resistant mutants in an evolutionarily conserved region of the beta' subunit of Escherichia coli RNA polymerase

[5] F Reusser. J Bacteriol. Streptolydigin, an inhibitor of oxidative phosphorylation in rat liver mitochondria

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Keywords: Streptolydigin, Portamycin supplier, DNA/RNA Synthesis, inhibitors, activators

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