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STING agonist-12 

Cat. No. M29463

All AbMole products are for research use only, cannot be used for human consumption.

STING agonist-12  Structure

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Quality Control & Documentation
Biological Activity

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.

Chemical Information
Molecular Weight 490.88
Formula C25H19ClF4N2O2
CAS Number 2259624-71-8
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage 4°C, protect from light
Related STING Products
Vadimezan

Vadimezan (DMXAA; ASA-404) acts as a tumor vascular disrupting agent (tumor-VDA), is also a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.

G10

G10 is a activator of STING-dependent signaling.

3′3′-cGAMP

3',3'-cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. 3',3'-cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

diABZI (tautomerism)

diABZI (STING agonist 1; Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

C-176

C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING.

  Catalog
Abmole Inhibitor Catalog




Keywords: STING agonist-12  supplier, STING, inhibitors, activators

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