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STF-31 is a selective glucose transporter GLUT1 inhibitor, with an IC50 of 1 μM. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
STF-31 is also a NAMPT inhibitor. In NAPRT1-expressing cells, STF-31 shows cytotoxicity by inhibiting the enzymatic activity of NAMPT.
STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. STF-31 reduces the efferocytosis of wild type and SLC2A1-overexpressing LR73 cells.
STF-31 (10 mg/kg; i.p.) promotes accumulation of necrotic thymocytes after Dexamethasone-induced apoptosis in vivo.
| Molecular Weight | 423.53 |
| Formula | C23H25N3O3S |
| CAS Number | 724741-75-7 |
| Solubility (25°C) | DMSO 34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Adams DJ,et.al. ACS Chem Biol NAMPT is the cellular target of STF-31-like small-molecule probes.
| Related GLUT Products |
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| WZB117
WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. |
| 1,9-Dideoxyforskolin
1,9-Dideoxyforskolin is a inactive analog of forskolin |
| Dihydrokainic acid
Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. |
| BAY-876
BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1 with an IC50 of 2 nM. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis. |
| BAY-588
BAY-588 is an inactive control probe for BAY-876. |
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