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SRT2104 is a selective brain-permeable activator of SIRT1. SRT2104 (3 μM) reduces p65/RelA acetylation levels in C2C12 cells.
In vivo, SRT2104 (100 mg/kg, p.o.) improves whole-body physiology and extends lifespan in mice fed a standard diet. SRT2104 increases mitochondrial content and suppresses the inflammatory response in SD-fed mice. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.
| Cell Experiment | |
|---|---|
| Cell lines | Primary neuronal cells |
| Preparation method | After 24 h or transfection, the cells were pretreated with indicated concentration of SRT2104 for 1 h followed by OGD/R insult or LPS stimulation. Afterwards, the cells were harvested and subjected to luciferase activity assay according to the manufacturer's instructions. |
| Concentrations | 2 μM |
| Incubation time | 1 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | Not mentioned |
| Dosages | 100 mg/kg |
| Administration | Intracerebroventricular injection |
| Molecular Weight | 516.64 |
| Formula | C26H24N6O2S2 |
| CAS Number | 1093403-33-8 |
| Solubility (25°C) | DMSO: 5 mg/mL (Need ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Fuzhe Ma, et al. P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy
[5] Jos M Villalba, et al. Sirtuin activators and inhibitors
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