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SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | A mouse model with choroidal neovascularization (CNV) |
| Formulation | DMSO |
| Dosages | ~20 pmol |
| Administration | i.v. |
| Molecular Weight | 349.35 |
| Formula | C18H18F3N3O |
| CAS Number | 218156-96-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related SRPK Products |
|---|
| SPHINX31
SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) with IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). |
| WAY-652848
WAY-652848 is a selective inhibitor of SRPK1 with an IC50 value of 0.58 μM.WAY-652848 effectively reduces choroidal neovascularization (CNV) in vivo, and can be used in the study of age-related macular degeneration. |
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