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SRI-011381 hydrochloride is a TGF-beta signaling agonist. SRI-011381 is a biologically active inducer of TGF-β signaling in cell culture and in vivo. SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.
| Molecular Weight | 365.94 |
| Formula | C20H32ClN3O |
| CAS Number | 2070014-88-7 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL Water 20 mg/mL |
| Storage | 4°C, dry, sealed |
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