All AbMole products are for research use only, cannot be used for human consumption.
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
J Colloid Interface Sci. 2026 Jan 06;708:139847.
Manganese-based metal-organic frameworks augment postoperative immunotherapy of high-intensity focused ultrasound
SR-717 purchased from AbMole
Chem Eng J. 2025 Jan 18.
HIFU postoperative hypoxia enables metal-organic frameworks amplifying banoxantrone and STING activation for enhanced immunotherapy
SR-717 purchased from AbMole
J Control Release. 2025 May 01.
Hypoxia-responsive albumin nanoparticles co-delivering banoxantrone and STING agonist enhance immunotherapy of high-intensity focused ultrasound
SR-717 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Bone marrow cells |
| Preparation method | Following 8 days of differentiation, the cells were treated with free SR-717, HAC NPs, or HACS NPs (SR-717 concentration of 50 mg/L) at 37 °C for 24 h. After treatment, the cells were harvested, washed with PBS, and stained with antibodies CD11c, CD86, CD80, CD40, MHC-I, and MHC-II. |
| Concentrations | 50 mg/L |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | 50% PEG300 and 50% saline |
| Dosages | 30 mg/kg |
| Administration | Injected intraperitoneally |
| Molecular Weight | 351.19 |
| Formula | C15H8F2LiN5O3 |
| CAS Number | 2375421-09-1 |
| Solubility (25°C) | DMSO 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related STING Products |
|---|
| Vadimezan
Vadimezan (DMXAA; ASA-404) acts as a tumor vascular disrupting agent (tumor-VDA), is also a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. |
| G10
G10 is a activator of STING-dependent signaling. |
| 3′3′-cGAMP
3',3'-cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. 3',3'-cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. |
| diABZI (tautomerism)
diABZI (STING agonist 1; Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| C-176
C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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