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SR 33805 oxalate is a potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.
| Molecular Weight | 654.77 |
| Formula | C32H40N2O5S.C2H2O4 |
| CAS Number | 121346-33-6 |
| Solubility (25°C) | DMSO 56.47 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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