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SR 12813 is an efficient pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). SR 12813 activates the farnesoid X receptor (FXR) at μM concentrations. SR 12813 displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
| Molecular Weight | 504.53 |
| Formula | C24H42O7P2 |
| CAS Number | 126411-39-0 |
| Solubility (25°C) | DMSO 50.45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Pregnane X Receptor Products |
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| Citral
Citral is a monoterpene found in Cymbopogon citratus essential oil, with antihyperalgesic, anti-nociceptive and anti-inflammatory effects. Citral has been shown to activate PXR and induce its target genes. Citral is also a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines. |
| Pregnenolone 16α-carbonitrile
Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury. |
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