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Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively.
| Molecular Weight | 379.45 |
| Formula | C22H25N3O3 |
| CAS Number | 1054-88-2 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Claudia Sorbi et al. Pharmacol Rep. Spiroxatrine derivatives towards 5-HT1A receptor selectivity
[2] D L Nelson et al. Eur J Pharmacol. Spiroxatrine: a selective serotonin1A receptor antagonist
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