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Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3. Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents).
| Molecular Weight | 1619.88 |
| Formula | C74H114N20O19S |
| CAS Number | 1370290-58-6 |
| Form | Solid |
| Solubility (25°C) | Water 20 mg/mL |
| Storage | Store at ≤ -20°C, protect from light, dry, sealed |
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