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Spermine is a biogenic polyamine formed from spermidine and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor.
| Molecular Weight | 202.34 |
| Formula | C10H26N4 |
| CAS Number | 71-44-3 |
| Solubility (25°C) | Water ≥ 50 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
[4] Silvia Grancara, et al. Bidirectional fluxes of spermine across the mitochondrial membrane
[5] R Amendola, et al. Spermine metabolism and anticancer therapy
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