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SPD304

Cat. No. M10950

All AbMole products are for research use only, cannot be used for human consumption.

SPD304 Structure

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Biological Activity

SPD304 is a selective inhibitor of tumor necrosis factor α (TNF-α) that promotes the separation of tumor necrosis factor trimers, thereby blocking their interaction with receptors. SPD304 inhibits tumor necrosis factor in vitro α and receptor 1 binding IC50 The value is 22 μM.

Chemical Information
Molecular Weight 547.61
Formula C32H32F3N3O2
CAS Number 869998-49-2
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ghada Attia, et al. Data Brief. Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304

[2] Ada Mascret, et al. Eur J Pharmacol. New contributions to the drug profile of TNFα inhibitor SPD304: Affinity, selectivity and ADMET considerations

[3] Yang Yu, et al. Hypertension. Brain TACE (Tumor Necrosis Factor-α-Converting Enzyme) Contributes to Sympathetic Excitation in Heart Failure Rats

[4] Gaoyin Wu, et al. J Mol Model. Fullerenes and their derivatives as inhibitors of tumor necrosis factor-α with highly promoted affinities

[5] Christos P Papaneophytou, et al. ACS Med Chem Lett. Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

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Keywords: SPD304 supplier, inhibitors, activators

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