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Spastazoline is a potent and selective, cell permeable inhibitor for aaa+ (atpases associated with diverse cellular activities) proteins, inhibiting the microtubule-severing aaa+ protein spastin, with IC50 of 99 nM for human spastin. Spastazoline shows no effect on ATPase activity of a recombinant human VPS4.
| Molecular Weight | 382.51 |
| Formula | C20H30N8 |
| CAS Number | 2351882-11-4 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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