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Sp-cAMPS sodium salt 

Cat. No. M28396

All AbMole products are for research use only, cannot be used for human consumption.

Sp-cAMPS sodium salt  Structure

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Biological Activity

Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC50 of 40 μM.

Chemical Information
Molecular Weight 367.25
Formula C10H11N5NaO5PS
CAS Number 142439-95-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Water 86.67 mg/mL (ultrasonic)
Storage -20°C, protect from light, dry, sealed
References

[1] Christopher L Brett, et al. J Physiol. Regulation of Cl--HCO3- exchangers by cAMP-dependent protein kinase in adult rat hippocampal CA1 neurons

[2] Rüdiger Popp, et al. Circ Res. Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid

[3] G A Smith, et al. J Physiol. Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurones

[4] A V Chibalin, et al. J Biol Chem. Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na+,K+-ATPase endocytosis

[5] B Frohnwieser, et al. J Physiol. Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain

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Keywords: Sp-cAMPS sodium salt  supplier, PKA, inhibitors, activators

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