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Sovilnesib (AMG 650)

Cat. No. M22468

All AbMole products are for research use only, cannot be used for human consumption.

Sovilnesib (AMG 650) Structure
Synonym:

AMG 650

Size Price Availability Quantity
5mg USD 265 In stock
10mg USD 420 In stock
25mg USD 850 In stock
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Biological Activity

Sovilnesib (AMG 650) is a potent, orally active kinesin-like protein KIF18A inhibitor with an IC50 value of 0.071 μM. Sovilnesib (AMG 650; 0-10 pM; 96 and 144 h; cancer cell lines) has anti-proliferative activity and inhibits tumor cell growth in a dose-dependent manner.

Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.

Chemical Information
Molecular Weight 564.65
Formula C26H34F2N6O4S
CAS Number 2410796-79-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qi Xu, et al. Int J Environ Res Public Health. How Do R&D and Renewable Energy Consumption Lead to Carbon Neutrality? Evidence from G-7 Economies

[2] Michael E Wechsler, et al. Lancet Respir Med. Evaluation of the oral corticosteroid-sparing effect of tezepelumab in adults with oral corticosteroid-dependent asthma (SOURCE): a randomised, placebo-controlled, phase 3 study

[3] Gajanan Ghodake, et al. J Sci Food Agric. Silver nanoparticle probe for colorimetric detection of aminoglycoside antibiotics: picomolar-level sensitivity toward streptomycin in water, serum, and milk samples

[4] Mehmet Akif Destek, et al. Sci Total Environ. Investigation of environmental Kuznets curve for ecological footprint: The role of energy and financial development

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Keywords: Sovilnesib (AMG 650), AMG 650 supplier, Microtubule, inhibitors, activators

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