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Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Sotalol definitely distinctly located binding site to interfere with K+ permeation; both enantiomers associated with a rate close to 5 ˟ 105 /mol/ sec with the open pore thereby flicker-blocking cardiac K (ATP) channels.
| Molecular Weight | 308.82 |
| Formula | C12H20N2O3S.HCl |
| CAS Number | 959-24-0 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Nicholas Z Kerin. Intravenous Sotalol: An Under Used Treatment Strategy
[2] Rahul Samanta, et al. The Use of Intravenous Sotalol in Cardiac Arrhythmias
[4] J M Nappi, et al. Sotalol: a breakthrough antiarrhythmic?
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