All AbMole products are for research use only, cannot be used for human consumption.
Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is also a ferroptosis activator.
IJ Pharmaceutical Research. 2025 Aug 06; .
Low-Dose Celastrol Modulates IL-6 Secretion to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells
Sorafenib purchased from AbMole
Proc Natl Acad Sci U S A. 2024 Apr 30;121(18).
Liver cancer development driven by the AP-1/c-Jun˜Fra-2 dimer through c-Myc
Sorafenib purchased from AbMole
Cell Death Dis. 2020 Oct 23;11(10):902.
The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma
Sorafenib purchased from AbMole
J Virol. 2020 Feb 14;94(5):e01791-19.
Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
Sorafenib purchased from AbMole
Patent. WO2020122816A1 2020 Jun 18.
Patent. WO2020122816A1
Sorafenib purchased from AbMole
Phytomedicine. 2015 Dec 1;1139-49.
Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells.
Sorafenib purchased from AbMole
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Source | Phytomedicine (2015). Figure 1. Sorafenib was purchased from AbMole (Shanghai, China) |
| Method | Cell viability was determined by MTT assay | |
| Cell Lines | HCC HepG2 | |
| Concentrations | 0~100 µM | |
| Incubation Time | 24, 48, 72 hours | |
| Results | PPI dose- and time-dependently inhibited the proliferation of HepG2 cells, with IC50 values of 1.047 ± 0.376µM within 24 h. Sorafenib was used as a positive control in HepG2 cells. |
| Cell Experiment | |
|---|---|
| Cell lines | PLC/PRF/5, Hep3B, HepG2, HuH7 |
| Preparation method | PLC/PRF/5, Hep3B, HepG2 and HuH7 Cells were seeded in 96-well plates (3,000 cells/well) and incubated overnight for attachment, and were then treated with indicated agents in 10% FBS supplemented medium for 72 hours. The medium was replaced with MTT (0.5 mg/ml) at 37°C for 2 hours. After removal of medium, the cells were lysed with 200 μl per well dimethyl sulfoxide (DMSO), and absorbance at 570 nm was measured and the values of 50% inhibition concentration (IC50) for each drug were determined. |
| Concentrations | 0, 0.25, 0.5,1, 2 µM |
| Incubation time | 72 hours |
| Animal Experiment | |
|---|---|
| Animal models | PLC/PRF/5 xenograft model in female athymic nude mice of 4–5 weeks of age |
| Formulation | Dissolved in Cremophor EL/ethanol (50:50; Sigma Cremophor EL, 95% ethanol) at 4 × concentration. |
| Dosages | 60 mg/kg |
| Administration | Po, qd |
| Molecular Weight | 464.82 |
| Formula | C21H16ClF3N4O3 |
| CAS Number | 284461-73-0 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Xin Chen, et al. Nat Rev Clin Oncol. Broadening horizons: the role of ferroptosis in cancer
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Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. |
| PLX-4720
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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