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Solanesol mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants. Solanesol binds at ATP binding site and inhibit the phosphorylation of Focal Adhesion Kinase (FAK). Solanesol upregulates HO-1 and Hsp70 expression in L02 cells which activate Nrf2 and HSF1. It induces Nrf2 by enhancement of Keap1 interaction with Hsp90. Solanesol-activated HSF1 is involved in chaperones interaction.
| Cell Experiment | |
|---|---|
| Cell lines | human hepatic cell L02 |
| Preparation method | Cell viability is determined by MTT assays. Cells are seeded into 96-well plates (5 × 104 cells/well) 24 h before treatment. The cells are then treated with various concentrations of solanesol followed by incubating with 5 mg/ml of MTT working solution for 4 h at 37 °C. After being treated with 100 μL of DMSO to dissolve the crystals, the cells are detected under an Microplate Reader to measure the absorbance at 570 nm. |
| Concentrations | 10, 50, 100, 250, 500, 1000 μM |
| Incubation time | 12 h |
| Animal Experiment | |
|---|---|
| Animal models | Male albino rats |
| Formulation | Gelling agent Carbopol-934 |
| Dosages | 0.2 g of gel containing solanesol (1 % w/v) |
| Administration | applied to the plantar surface of the right hind paw by gently rubbing with the index finger |
| Molecular Weight | 631.07 |
| Formula | C45H74O |
| CAS Number | 13190-97-1 |
| Solubility (25°C) | Soluble in Chloroform |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FAK Products |
|---|
| NVP-TAE226
Nvp-tae 226 (TAE226) is a potent atP-competitive dual FAK and IGF-1R inhibitor with IC50 of 5.5 nM and 140 nM, respectively. Nvp-tae 226 (TAE226) also effectively inhibited Pyk2, insulin receptor (InsR), with IC50 of 3.5 nM and 40 nM. |
| PF-562271
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
| PF-573228
PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. |
| PF-00562271
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. |
| Defactinib
Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor, with potential antiangiogenic and antineoplastic activities. |
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