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SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
| Molecular Weight | 616.62 |
| Formula | C32H43Cl2N5O3 |
| CAS Number | 1104662-66-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Weitao Wang, et al. Semin Plast Surg. Free-Flap Reconstruction of Skull Base and Orbital Defects
[4] Martin Bröring, et al. Chem Commun (Camb). Free-base tripyrrins
[5] M Perez-Reyes, et al. Clin Pharmacol Ther. Free-base cocaine smoking
| Related Melanocortin Receptor Products |
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α-MSH (α-Melanocyte-stimulating hormone) is a tridecapeptide, mostly produced by the cells in the brain, pituitary and circulation. |
| Melanotan I acetate
Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH). *This compound is unstable in solutions, freshly prepared is recommended. |
| Setmelanotide
Setmelanotide is a selective agonist of the MC4 receptor, with EC50 values of 0.27 nM and 0.28 nM for human and rat MC4R, respectively. |
| Bremelanotide Acetate
Bremelanotide Acetate (PT-141 Acetate) is a peptide containing seven amino acids and is also a macrocyclic compound. In addition, Bremelanotide Acetate is an agonist of the melanocortin 4 receptor (MC4R). |
| JNJ-10229570
JNJ-10229570 (UNII-N9IX402L35) is is a novel MC1R and MC5R antagonist, which inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 values of 270 nM and 200 nM, respectively. |
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