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SNC 80 is a highly selective non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM, 2000-fold selective over μ-opioid receptors. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 (10 mg/kg; intraperitoneal injection; once) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan in C57BL6/J mice.
| Molecular Weight | 449.64 |
| Formula | C28H39N3O2 |
| CAS Number | 156727-74-1 |
| Solubility (25°C) | DMSO 30 mg/mL 1eq. HCl 40 mg/mL (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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