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SNAP 94847 

Cat. No. M30163

All AbMole products are for research use only, cannot be used for human consumption.

SNAP 94847  Structure

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Quality Control & Documentation
Biological Activity

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.

Chemical Information
Molecular Weight 478.57
Formula C29H32F2N2O2
CAS Number 487051-12-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] A N A Verty, et al. Int J Obes (Lond). Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice

[2] Sunila G Nair, et al. Psychopharmacology (Berl). Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats

[3] Douglas A Marsteller, et al. Eur J Pharmacol. The MCH1 receptor antagonist SNAP 94847 induces sensitivity to dopamine D2/D3 receptor agonists in rats and mice

[4] Daniel G Smith, et al. Behav Brain Res. The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents

[5] D J David, et al. J Pharmacol Exp Ther. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocam䲧癐Ỵ癑㧀癏羹瘸

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Keywords: SNAP 94847  supplier, GPR/FFAR, inhibitors, activators

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