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SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB.
SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells with a low level of toxicity to normal prostate cells compared with SN50, which blocks nuclear import of the RelA:p50 dimer. SN52 has a strong radiosensitization effect on prostate cancer cells.
SN52 (40 μg/ml; 30 mins before DMXAA) inhibits DMXAA-induced nuclear translocation of RelB in BMDCs.
Both SN50 and SN52 enhance the radiosensitivity. SN52 seems to efficiently radiosensitize PC-3 cells at a low dose range of between 1 and 2 Gy, but its radiosensitization effect is slightly lower than that of SN50 at the high dose range of between 4 and 6 Gy.
Sequence: AAVALLPAVLLALLAPVQRKRRKALP
| Molecular Weight | 2749.43 |
| Formula | C128H230N38O28 |
| CAS Number | 1071173-56-2 |
| Solubility (25°C) | Water 25 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[2] Giovanna M Bernal, et al. Cell Biosci. p52 signaling promotes cellular senescence
[3] Irene Saha, et al. Cell Immunol. RelB suppresses type I Interferon signaling in dendritic cells
| Related NF-κB Products |
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| QNZ
QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. |
| Caffeic Acid Phenethyl Ester
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Methylthiouracil
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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