All AbMole products are for research use only, cannot be used for human consumption.
SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
J Vis Exp. 2025 Jan 31;Jan 31:(215).
Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Smoothened Agonist (SAG) HCl purchased from AbMole
Front Mol Biosci. 2023 Nov 23;10:1268722.
Paralog-specific TTC30 regulation of Sonic hedgehog signaling
Smoothened Agonist (SAG) HCl purchased from AbMole
| Molecular Weight | 526.52 |
| Formula | C28H29Cl2N3OS |
| CAS Number | 2095432-58-7 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[1] Chen JK, et.al. Proc Natl Acad Sci U S A. Small molecule modulation of Smoothened activity.
| Related Smo Products |
|---|
| GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
| Purmorphamine
Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO. |
| BMS-833923
BMS-833923 is an orally bioavailable Smoothened antagonist. |
| Halcinonide
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. |
| SANT-1
SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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