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SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2). In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)].
| Molecular Weight | 656.82 |
| Formula | C29H56N10O7 |
| CAS Number | 171436-38-7 |
| Solubility (25°C) | Water 90 mg/mL DMSO 80 mg/mL |
| Storage | -20°C, sealed |
| Related PAR Products |
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| ML161
Parmodulin 2 (ML161) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. |
| Vorapaxar
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. |
| Vorapaxar Sulfate
Vorapaxar is a first-in-class, potent and orally-active protease-activated receptor 1 (PAR-1) antagonist that blocks thrombin-mediated platelet activation without interfering with thrombin-mediated fibrin deposition. |
| ML354
ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist. |
| PAR-4 (1-6) (human)
PAR-4 (1-6) (human) is an N-terminal fragment of protease-activated receptor 4 (PAR4) that acts as a PAR4 agonist. |
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