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SKPin C1 is a inhibitor of Skp2-mediated p27 degradation. SKPin C1 induces p27 accumulation in metastatic melanoma cell lines. SKPin C1 promotes G1/S cell cycle arrest in T47D cells and LNCaP cells. SKPin C1 induces G2/M cell cycle arrest in MCF-7 cells.
| Molecular Weight | 465.34 |
| Formula | C18H13BrN2O4S2 |
| CAS Number | 432001-69-9 |
| Solubility (25°C) | DMSO 4.65 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Grant, et al. TiPS. Anilide tertiary carbinols: a novel series of K+ channel openers.
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